Comparison of outcomes following combined ECCE-trabeculectomy versus phacoemulsification-trabeculectomy.

Comparison of outcomes following combined ECCE-trabeculectomy versus phacoemulsification-trabeculectomy.

OBJECTIVE
To analyze and compare the primary outcome between trabeculectomies combined with extracapsular cataract extraction (ECCE) than in those with phacoemulsification (Phaco).


METHOD
The authors retrospectively reviewed a consecutive 357 cases surgeon (475 eyes) of the combined cataract extraction, intraocular lens implantation and trabeculectomy enhanced Mitomycin. Patients were divided into two groups, those who underwent extracapsular cataract extraction (80 eyes) and those who had phacoemulsification (395 eyes). Analysis of postoperative visual acuity, intraocular pressure (IOP), number of glaucoma medications, side effects after surgery and required additional procedures, performed. Minimum follow-up was 12 months with an average of 53 months.


RESULTS
There is no significant difference (p = 1.000) between the groups in terms of the rate of increase in visual acuity, 66% (ECCE) than 59% (Phaco). Postoperative IOP with both techniques down significantly (p <0.0001). Previous IOP reduction obtained by Phacoemulsification, but there was no difference at the end of the follow-up period (14.4 vs. 14.1 mmHg ECCE Phaco mmHg, p = 1.0000).

Postoperative pressure spikes occurred in 6% versus 10% (p = 0.3995) from the eye. There is no significant difference (55% compared to 63% Phaco ECCE, p = 0.1674) between the two groups in terms of reducing glaucoma medication was found. The number of postoperative complications (89% vs 68.5%) was significantly higher (p = 0.0001) in the ECE-group, as well as the number of eyes required further intervention (86% versus 64%, p = 0.0001)


CONCLUSION
Both techniques were effective joint operations and generate long-term results were similar. However phacoemulsification can reduce post operative complications associated with this operation.

 Comparison of outcomes following combined ECCE-trabeculectomy versus phacoemulsification-trabeculectomy.
Comparison of outcomes following combined ECCE-trabeculectomy versus phacoemulsification-trabeculectomy.

Aging and COPD affect different domains of nutritional status: early childhood studies.

Chronic obstructive pulmonary disease (COPD) and aging can lead to malnutrition. We aim to explore whether COPD and aging define malnutrition in different manners. 460 stable COPD outpatients (376 men and 84 women) from the consequences of COPD in the database Extrapulmonary Elderly (ECCE) study investigated (age 75.0 ± 5.9 yr; forced expiratory volume in 1 s 54.7 ± 18 3% predicted). The nutritional status was evaluated using the Mini Nutritional Assessment® (MNA) questionnaire. Of MNA, exploring the domain of the three values ​​are calculated nutritional status: body composition, energy intake and body function score.

Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage negatively correlated with five items MNA exploring mobility, patient perception of nutrition itself and health status, and arm and calf circumference (the lowest Spearman’s rho (rs) = – 0,011; the highest p = 0.039). GOLD stage independently correlated with body composition and body function score (model r 2 = 0.073).

AFX, phosphorylated (Ser193)

MBS620641-01mL 0.1mL
EUR 720

AFX, phosphorylated (Ser193)

MBS620641-5x01mL 5x0.1mL
EUR 3080

p53, phosphorylated (Ser315)

MBS623383-01mL 0.1mL
EUR 720

p53, phosphorylated (Ser315)

MBS623383-5x01mL 5x0.1mL
EUR 3080

Tau, phosphorylated (Ser396)

MBS633416-005mg 0.05mg
EUR 810

Tau, phosphorylated (Ser396)

MBS633416-5x005mg 5x0.05mg
EUR 3495

Bad, phosphorylated (Ser136)

MBS632866-02mL 0.2mL
EUR 660

Bad, phosphorylated (Ser136)

MBS632866-5x02mL 5x0.2mL
EUR 2810

p53, phosphorylated (Ser392)

MBS629481-01mL 0.1mL
EUR 840

p53, phosphorylated (Ser392)

MBS629481-5x01mL 5x0.1mL
EUR 3625

Raf, phosphorylated (Ser338)

MBS609892-01mL 0.1mL
EUR 720

Raf, phosphorylated (Ser338)

MBS609892-5x01mL 5x0.1mL
EUR 3080

Tau, phosphorylated (Ser396)

MBS609274-01mL 0.1mL
EUR 720

Tau, phosphorylated (Ser396)

MBS609274-5x01mL 5x0.1mL
EUR 3080

Akt, phosphorylated (Ser473)

MBS609111-01mL 0.1mL
EUR 685

Akt, phosphorylated (Ser473)

MBS609111-5x01mL 5x0.1mL
EUR 2925

RAD9, phosphorylated (Ser1260)

MBS611570-01mg 0.1mg
EUR 970

RAD9, phosphorylated (Ser1260)

MBS611570-5x01mg 5x0.1mg
EUR 4210

RAD9, phosphorylated (Ser1129)

MBS616243-01mg 0.1mg
EUR 970

RAD9, phosphorylated (Ser1129)

MBS616243-5x01mg 5x0.1mg
EUR 4210

CREB, phosphorylated (Ser133)

MBS631748-01mL 0.1mL
EUR 695

CREB, phosphorylated (Ser133)

MBS631748-5x01mL 5x0.1mL
EUR 2985

Rac1, phosphorylated (Ser71)

MBS627363-10Blots 10Blots
EUR 875

Rac1, phosphorylated (Ser71)

MBS627363-5x10Blots 5x10Blots
EUR 3785

Hsp27, phosphorylated (Ser15)

MBS615790-005mg 0.05mg
EUR 705

Hsp27, phosphorylated (Ser15)

MBS615790-02mg 0.2mg
EUR 1140

Hsp27, phosphorylated (Ser15)

MBS615790-5x02mg 5x0.2mg
EUR 4985

Hsp27, phosphorylated (Ser78)

MBS615913-005mg 0.05mg
EUR 465

Hsp27, phosphorylated (Ser78)

MBS615913-02mg 0.2mg
EUR 760

Hsp27, phosphorylated (Ser78)

MBS615913-5x02mg 5x0.2mg
EUR 3265

Hsp27, phosphorylated (Ser82)

MBS611413-005mL 0.05mL
EUR 545

Hsp27, phosphorylated (Ser82)

MBS611413-02mL 0.2mL
EUR 895

Hsp27, phosphorylated (Ser82)

MBS611413-5x02mL 5x0.2mL
EUR 3885

cdc25A, phosphorylated (Ser75)

MBS623301-01mg 0.1mg
EUR 560

cdc25A, phosphorylated (Ser75)

MBS623301-5x01mg 5x0.1mg
EUR 2360

Dynamin, phosphorylated (Ser774)

MBS625864-01mL 0.1mL
EUR 840

Dynamin, phosphorylated (Ser774)

MBS625864-5x01mL 5x0.1mL
EUR 3625

Dynamin, phosphorylated (Ser778)

MBS629731-01mL 0.1mL
EUR 840

Dynamin, phosphorylated (Ser778)

MBS629731-5x01mL 5x0.1mL
EUR 3625

LKB 1, phosphorylated (Ser334)

MBS621265-01mL 0.1mL
EUR 720

LKB 1, phosphorylated (Ser334)

MBS621265-5x01mL 5x0.1mL
EUR 3080

Ets 1, phosphorylated (Ser282)

MBS631088-10Blots 10Blots
EUR 810

Ets 1, phosphorylated (Ser282)

MBS631088-5x10Blots 5x10Blots
EUR 3495

Ets 1, phosphorylated (Ser251)

MBS628526-01mL 0.1mL
EUR 810

Ets 1, phosphorylated (Ser251)

MBS628526-5x01mL 5x0.1mL
EUR 3495

Jun D, phosphorylated (Ser255)

MBS627541-01mg 0.1mg
EUR 560

Jun D, phosphorylated (Ser255)

MBS627541-5x01mg 5x0.1mg
EUR 2360

PAK1,2, phosphorylated (Ser144/141)

MBS619619-01mL 0.1mL
EUR 720

PAK1,2, phosphorylated (Ser144/141)

MBS619619-5x01mL 5x0.1mL
EUR 3080

Phospholamban, phosphorylated (Ser16)

MBS617405-01mg 0.1mg
EUR 955

Phospholamban, phosphorylated (Ser16)

MBS617405-5x01mg 5x0.1mg
EUR 4145

p27Kip1, phosphorylated, (Ser10)

MBS627899-005mg 0.05mg
EUR 765

p27Kip1, phosphorylated, (Ser10)

MBS627899-5x005mg 5x0.05mg
EUR 3285

c-Jun, phosphorylated (Ser243)

MBS625400-01mg 0.1mg
EUR 560

c-Jun, phosphorylated (Ser243)

MBS625400-5x01mg 5x0.1mg
EUR 2360

AML-1, phosphorylated (Ser249)

MBS616814-01mL 0.1mL
EUR 720

AML-1, phosphorylated (Ser249)

MBS616814-5x01mL 5x0.1mL
EUR 3080

Elk-1, phosphorylated (Ser389)

MBS616209-01mg 0.1mg
EUR 560

Elk-1, phosphorylated (Ser389)

MBS616209-5x01mg 5x0.1mg
EUR 2360

Elk-1, phosphorylated (Ser383)

MBS604231-05mg 0.5mg
EUR 760

Elk-1, phosphorylated (Ser383)

MBS604231-5x05mg 5x0.5mg
EUR 3265

Elk-1, phosphorylated (Ser383)

MBS610818-01mL 0.1mL
EUR 825

Elk-1, phosphorylated (Ser383)

MBS610818-5x01mL 5x0.1mL
EUR 3555

Elk-1, phosphorylated (Ser383)

MBS617487-01mL 0.1mL
EUR 720

Elk-1, phosphorylated (Ser383)

MBS617487-5x01mL 5x0.1mL
EUR 3080

Elk-1, phosphorylated (Ser383)

MBS601715-05mg 0.5mg
EUR 760

Elk-1, phosphorylated (Ser383)

MBS601715-5x05mg 5x0.5mg
EUR 3265

Elk-1, phosphorylated (Ser383)

MBS601142-01mL 0.1mL
EUR 720

Elk-1, phosphorylated (Ser383)

MBS601142-5x01mL 5x0.1mL
EUR 3080

Paxillin, phosphorylated (Ser17)

MBS631416-01mL 0.1mL
EUR 740

Paxillin, phosphorylated (Ser17)

MBS631416-5x01mL 5x0.1mL
EUR 3175

Caldesmon, phosphorylated, Ser789

MBS609548-1mL 1mL
EUR 1570

Caldesmon, phosphorylated, Ser789

MBS609548-5x1mL 5x1mL
EUR 6925

c-Jun, phosphorylated (Ser73)

MBS625208-01mL 0.1mL
EUR 695

c-Jun, phosphorylated (Ser73)

MBS625208-5x01mL 5x0.1mL
EUR 2985

Ras, GRF1, phosphorylated (Ser916)

MBS613565-01mL 0.1mL
EUR 720

Ras, GRF1, phosphorylated (Ser916)

MBS613565-5x01mL 5x0.1mL
EUR 3080

Bcl-XL, phosphorylated (Ser62)

MBS626983-01mL 0.1mL
EUR 810

Bcl-XL, phosphorylated (Ser62)

MBS626983-5x01mL 5x0.1mL
EUR 3495

Bcl-XL, phosphorylated (Ser62)

MBS630722-01mL 0.1mL
EUR 950

Bcl-XL, phosphorylated (Ser62)

MBS630722-5x01mL 5x0.1mL
EUR 4115

Cyclin B1, phosphorylated (Ser147)

MBS625299-01mL 0.1mL
EUR 720

Cyclin B1, phosphorylated (Ser147)

MBS625299-5x01mL 5x0.1mL
EUR 3080

Cyclin B1, phosphorylated (Ser133)

MBS609069-01mL 0.1mL
EUR 720

Cyclin B1, phosphorylated (Ser133)

MBS609069-5x01mL 5x0.1mL
EUR 3080

Cofilin, phosphorylated (Ser3)

MBS618868-01mL 0.1mL
EUR 805

Cofilin, phosphorylated (Ser3)

MBS618868-5x01mL 5x0.1mL
EUR 3465

Cofilin, phosphorylated (Ser3)

MBS613817-10Blots 10Blots
EUR 875

Cofilin, phosphorylated (Ser3)

MBS613817-5x10Blots 5x10Blots
EUR 3785

Cofilin, phosphorylated (Ser3)

MBS601180-01mL 0.1mL
EUR 695

Cofilin, phosphorylated (Ser3)

MBS601180-5x01mL 5x0.1mL
EUR 2985

IKK gamma, phosphorylated (Ser31)

MBS626613-01mg 0.1mg
EUR 610

IKK gamma, phosphorylated (Ser31)

MBS626613-5x01mg 5x0.1mg
EUR 2600

Phospholamban, Phosphorylated (Ser16) (AP)

MBS6493254-01mL 0.1mL
EUR 1235

Phospholamban, Phosphorylated (Ser16) (AP)

MBS6493254-5x01mL 5x0.1mL
EUR 5410

Phospholamban, Phosphorylated (Ser16) (PE)

MBS6493264-01mL 0.1mL
EUR 1235

Phospholamban, Phosphorylated (Ser16) (PE)

MBS6493264-5x01mL 5x0.1mL
EUR 5410

Histone H3, phosphorylated (Ser28)

MBS626533-01mL 0.1mL
EUR 910

Histone H3, phosphorylated (Ser28)

MBS626533-5x01mL 5x0.1mL
EUR 3950

Rac1/cdc42, phosphorylated (Ser71)

MBS617536-01mL 0.1mL
EUR 720

Rac1/cdc42, phosphorylated (Ser71)

MBS617536-5x01mL 5x0.1mL
EUR 3080

Histone H3, phosphorylated (Ser28)

MBS633587-01mg 0.1mg
EUR 650

Histone H3, phosphorylated (Ser28)

MBS633587-5x01mg 5x0.1mg
EUR 2765

Histone H3, phosphorylated (Ser10)

MBS633373-01mL 0.1mL
EUR 695

Histone H3, phosphorylated (Ser10)

MBS633373-5x01mL 5x0.1mL
EUR 2985

Histone H3, phosphorylated (Ser10)

MBS629527-01mL 0.1mL
EUR 695

Histone H3, phosphorylated (Ser10)

MBS629527-5x01mL 5x0.1mL
EUR 2985

Histone H3, phosphorylated (Ser10)

MBS631697-01mL 0.1mL
EUR 650

Histone H3, phosphorylated (Ser10)

MBS631697-5x01mL 5x0.1mL
EUR 2780

Histone H3, phosphorylated (Ser10)

MBS631596-01mL 0.1mL
EUR 855

Histone H3, phosphorylated (Ser10)

MBS631596-5x01mL 5x0.1mL
EUR 3700

Histone H3, phosphorylated (Ser28)

MBS630703-002mL 0.02mL
EUR 435

Histone H3, phosphorylated (Ser28)

MBS630703-01mL 0.1mL
EUR 715

Histone H3, phosphorylated (Ser28)

MBS630703-5x01mL 5x0.1mL
EUR 3075

Histone H3, phosphorylated (Ser10)

MBS632733-02mg 0.2mg
EUR 890

Histone H3, phosphorylated (Ser10)

MBS632733-5x02mg 5x0.2mg
EUR 3865

Histone H3, phosphorylated (Ser10)

MBS632529-01mg 0.1mg
EUR 910

Histone H3, phosphorylated (Ser10)

MBS632529-5x01mg 5x0.1mg
EUR 3950

Synapsin I, phosphorylated (Ser603)

MBS624245-01mL 0.1mL
EUR 805

Synapsin I, phosphorylated (Ser603)

MBS624245-5x01mL 5x0.1mL
EUR 3465

Raf1, phosphorylated (Ser338, Tyr341)

MBS609116-025mL 0.25mL
EUR 565

Raf1, phosphorylated (Ser338, Tyr341)

MBS609116-5x025mL 5x0.25mL
EUR 2380

Histone H2A.X, phosphorylated (Ser139)

MBS6506879-01mL 0.1mL
EUR 720

Histone H2A.X, phosphorylated (Ser139)

MBS6506879-5x01mL 5x0.1mL
EUR 3080

Ets 1, phosphorylated (Ser282, Ser285)

MBS626099-10Blots 10Blots
EUR 875

Ets 1, phosphorylated (Ser282, Ser285)

MBS626099-5x10Blots 5x10Blots
EUR 3785

Phospholamban, Phosphorylated (Ser16) (APC)

MBS6493255-01mL 0.1mL
EUR 1235

Phospholamban, Phosphorylated (Ser16) (APC)

MBS6493255-5x01mL 5x0.1mL
EUR 5410

Phospholamban, Phosphorylated (Ser16) (HRP)

MBS6493258-01mL 0.1mL
EUR 1235

Phospholamban, Phosphorylated (Ser16) (HRP)

MBS6493258-5x01mL 5x0.1mL
EUR 5410

IP3 Receptor phosphorylated (Ser1756)

MBS628778-01mL 0.1mL
EUR 720

IP3 Receptor phosphorylated (Ser1756)

MBS628778-5x01mL 5x0.1mL
EUR 3080

Caveolin 2, phosphorylated (Ser23)

MBS630208-005mg 0.05mg
EUR 670

Caveolin 2, phosphorylated (Ser23)

MBS630208-5x005mg 5x0.05mg
EUR 2870

Caveolin 2, phosphorylated (Ser36)

MBS627604-005mg 0.05mg
EUR 690

Caveolin 2, phosphorylated (Ser36)

MBS627604-5x005mg 5x0.05mg
EUR 2945

c-Fos, phosphorylated (Ser374) (Fos)

MBS632425-01mg 0.1mg
EUR 785

c-Fos, phosphorylated (Ser374) (Fos)

MBS632425-5x01mg 5x0.1mg
EUR 3385

Jun, phosphorylated (Ser243) (c-Jun)

MBS628296-01mL 0.1mL
EUR 720

Jun, phosphorylated (Ser243) (c-Jun)

MBS628296-5x01mL 5x0.1mL
EUR 3080

Paxillin, phosphorylated, Ser178 (PXN)

MBS611391-01mL 0.1mL
EUR 710

Paxillin, phosphorylated, Ser178 (PXN)

MBS611391-5x01mL 5x0.1mL
EUR 3040

Catenin, beta, phosphorylated (Ser675)

MBS609015-002mL 0.02mL
EUR 450

Catenin, beta, phosphorylated (Ser675)

MBS609015-01mL 0.1mL
EUR 755

Catenin, beta, phosphorylated (Ser675)

MBS609015-5x01mL 5x0.1mL
EUR 3245

Phospholamban, Phosphorylated (Ser16) (FITC)

MBS6493257-01mL 0.1mL
EUR 1235

Phospholamban, Phosphorylated (Ser16) (FITC)

MBS6493257-5x01mL 5x0.1mL
EUR 5410

PRL, phosphorylated (Ser163) (Prolactin)

MBS624071-02mL 0.2mL
EUR 695

PRL, phosphorylated (Ser163) (Prolactin)

MBS624071-5x02mL 5x0.2mL
EUR 2975

Catenin, alpha Phosphorylated (ser641)

MBS629606-01mg 0.1mg
EUR 560

Catenin, alpha Phosphorylated (ser641)

MBS629606-5x01mg 5x0.1mg
EUR 2360

Catenin, beta, phosphorylated (Ser37)

MBS626045-01mg 0.1mg
EUR 560

Catenin, beta, phosphorylated (Ser37)

MBS626045-5x01mg 5x0.1mg
EUR 2360

Catenin, beta, phosphorylated (Ser45)

MBS629375-01mL 0.1mL
EUR 720

Catenin, beta, phosphorylated (Ser45)

MBS629375-5x01mL 5x0.1mL
EUR 3080

Catenin, beta, phosphorylated (Ser45)

MBS630552-10Blots 10Blots
EUR 875

Catenin, beta, phosphorylated (Ser45)

MBS630552-5x10Blots 5x10Blots
EUR 3785

RelB, phosphorylated (Ser552) (I-Rel)

MBS612033-01mg 0.1mg
EUR 560

RelB, phosphorylated (Ser552) (I-Rel)

MBS612033-5x01mg 5x0.1mg
EUR 2360

IkB alpha, phosphorylated (Ser32/36)

MBS609246-01mL 0.1mL
EUR 695

IkB alpha, phosphorylated (Ser32/36)

MBS609246-5x01mL 5x0.1mL
EUR 2985

Cofilin 2, phosphorylated (Ser3)

MBS624852-02mg 0.2mg
EUR 940

Cofilin 2, phosphorylated (Ser3)

MBS624852-5x02mg 5x0.2mg
EUR 4080

Cofilin, Phosphorylated (Ser3) (AP)

MBS6469600-01mL 0.1mL
EUR 1085

Cofilin, Phosphorylated (Ser3) (AP)

MBS6469600-5x01mL 5x0.1mL
EUR 4730

Cofilin, Phosphorylated (Ser3) (PE)

MBS6469610-01mL 0.1mL
EUR 1085

Cofilin, Phosphorylated (Ser3) (PE)

MBS6469610-5x01mL 5x0.1mL
EUR 4730

Phospholamban, Phosphorylated (Ser16) (Biotin)

MBS6493256-01mL 0.1mL
EUR 1235

Phospholamban, Phosphorylated (Ser16) (Biotin)

MBS6493256-5x01mL 5x0.1mL
EUR 5410

Histone H3, phosphorylated (Ser10) (AP)

MBS6241831-01mL 0.1(mL
EUR 1175

Histone H3, phosphorylated (Ser10) (AP)

MBS6241831-5x01mL 5x0.1mL
EUR 5130

Histone H3, phosphorylated (Ser10) (AP)

MBS6241863-01mL 0.1(mL
EUR 1190

Histone H3, phosphorylated (Ser10) (AP)

MBS6241863-5x01mL 5x0.1mL
EUR 5215

Histone H3, phosphorylated (Ser10) (PE)

MBS6244495-01mL 0.1(mL
EUR 1175

Histone H3, phosphorylated (Ser10) (PE)

MBS6244495-5x01mL 5x0.1mL
EUR 5130

Histone H3, phosphorylated (Ser10) (PE)

MBS6244527-01mL 0.1(mL
EUR 1190

Histone H3, phosphorylated (Ser10) (PE)

MBS6244527-5x01mL 5x0.1mL
EUR 5215

Histone H3, phosphorylated (Ser10) (AP)

MBS6120754-02mL 0.2(mL
EUR 980

Histone H3, phosphorylated (Ser10) (AP)

MBS6120754-5x02mL 5x0.2mL
EUR 4250

Histone H3, phosphorylated (Ser10) (PE)

MBS6121689-02mL 0.2(mL
EUR 980

Histone H3, phosphorylated (Ser10) (PE)

MBS6121689-5x02mL 5x0.2mL
EUR 4250

Synapsin I, phosphorylated (Ser9)

MBS625733-01mL 0.1mL
EUR 890

Synapsin I, phosphorylated (Ser9)

MBS625733-5x01mL 5x0.1mL
EUR 3855

Age was negatively correlated with the four MNA items exploring the loss of appetite, fluid intake, mobility and autonomy in everyday life (cheapest rs = -0.013; p = 0.030 highest). Age is independently correlated with body function score (model r 2 = 0.037). Severe COPD and aging is an independent state and the same may lead to malnutrition. The MNA questionnaire allows valuable insight into the complexity of the components of the nutritional status and may provide useful guidance for treatment strategies.

Benoit

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