Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract.

Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract.

BACKGROUND
Age -related cataract is a clouding of the lens, which occurs as a result of lens protein denaturation. Age -related cataract remains the leading cause of blindness globally, except in the most advanced countries. A key question is what is the best way of eliminating the lens, especially in low-income settings.


OBJECTIVE
To compare two different techniques of elimination of the lens in cataract surgery: the user is operating a small incision (MSICS) and extracapsular cataract extraction (ECCE).


METHOD
We searched CENTRAL (which contains the Cochrane Eyes and Trials Vision Group Register) (2014, Issue 8), Ovid MEDLINE, Ovid MEDLINE in process and Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946-September 2014), EMBASE ( January 1980 until September 2014), Latin America and the Caribbean Health Sciences Literature database (LILACS) (January 1982 to September 2014), web of Science Conference Proceedings Citation Index, Science (CPCI-S), (January 1990 to September 2014), which metaRegister of Controlled Trials (mRCT) ), and the World Health Organization (WHO) International Clinical Trials Registry platform (ICTRP) . We do not use date or language restrictions in the electronic searches for trials. Last we are looking for an electronic database on 23 September 2014.


METHOD
We included randomized controlled trials (RCTs) only. Participants in the trials were people with age-related cataract. We included trials in which MSICS with posterior chamber intraocular lens (IOL) implant compared to ECCE with posterior chamber IOL implant.


METHOD
Data were collected independently by two authors. We aim to collect data on presenting visual acuity of 6/12 or better and best corrected visual acuity less than 6/60 in three months and one year after surgery. Other results included intraoperative complications, complications of long-term (one year or more after surgery), quality of life, and cost effectiveness. There is not enough data available from the trial and to conduct a meta-analysis.

 Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract.
Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract.


RESULTS
Three randomized trial allocate people with age-related cataract to MSICS or ECCE included in this review (n = 953 participants). Two trials conducted in India and one in Nepal. experimental methods, such as random allocation and allocation concealment, not clearly explained; only in one experiment was an attempt to conceal the outcome assessors. Three studies reported follow-up six to eight weeks after surgery. In two studies, a participant in the group MSICS achieved without the aid of visual acuity 6/12 or 6/18 or better than the ECCE group, but overall no more than 50% of people achieve a good functional vision in two studies.

10/806 (1.2%) of those enrolled in the two trials had poor outcomes after surgery (best corrected vision of less than 6/60) with no evidence of a difference in risk between the two techniques (risk ratio (RR) 1.58 , 95% confidence interval (CI) 0.45 to 5.55). Surgically induced astigmatism more common with ECCE procedure of MSICS in two trials that reported this outcome. In one study there more complications intra and post-surgery in MSICS group. One study reported that the cost of two similar procedures.

Anti-NMDA NR2B Subunit (100 ul) antibody

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99838-T 1ML
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CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF680R conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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CD1b(100-1A5) Antibody

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CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF488A conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF568 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF647 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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EUR 238.8
Description: Primary antibody against CD1b(100-1A5), CF640R conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF543 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF555 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF660R conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF680 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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EUR 238.8
Description: Primary antibody against CD1b(100-1A5), CF405M conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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EUR 238.8
Description: Primary antibody against CD1b(100-1A5), CF770 conjugate, Concentration: 0.1mg/mL

Asymmetrical Mixer Union for LCP. Couples to 250 uL syringes on one side and to 250 uL, 50 uL, or 100 uL syringes on the other.

MLCP-AMXU-1 1 UNIT
EUR 180
Description: Asymmetrical Mixer Union for LCP. Couples to 250 uL syringes on one side and to 250 uL, 50 uL, or 100 uL syringes on the other.

Symmetrical Mixer Union for LCP. Couples to 250 uL and 100 uL syringes on both ends

MLCP-SMXU-1 1 UNIT
EUR 180
Description: Symmetrical Mixer Union for LCP. Couples to 250 uL and 100 uL syringes on both ends

M-MLV Reverse Transcriptase, 200u/ul

M2410-100 10,000 units
EUR 181.2

Pico488 dsDNA quantification reagent, 200x solution in DMSO, 100 uL

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EUR 70.8

Corning 100-1000 uL Lambda Plus Single-Channel Pipettor autoclavable

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EUR 214.32

AIM-100

A3148-100 100 mg
EUR 2230.8
Description: AIM-100 is a small inhibitor of Ack1 tyrosine kinase with IC50 value of 24 nM [1]. AIM-100 mimicked ATP and inhibited the activity of Ack1 significantly and specifically.

LB-100

B4846-100 100 mg
EUR 1032

bcl-2(100/D5) Antibody

BNC040045-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5), CF405S conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC050045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), CF405M conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCB0045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC940045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNUB0045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), Concentration: 0.2mg/mL

bcl-2(100/D5) Antibody

BNCH0045-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC880045-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC680045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), CF568 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC470045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC430045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), CF543 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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EUR 238.8
Description: Primary antibody against bcl-2(100/D5), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF680 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC400045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), CF640R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF555 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF770 conjugate, Concentration: 0.1mg/mL

Human IgG/RF-adsorbent (Adsorb 50 serum samples of 100 ul)

RFAD11-50 50 tests
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Human IgG/RF-adsorbent (Adsorb 50 serum samples of 100 ul)

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MTBK_20640-100

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hAlbumin FRET 100

AH1005-100 1 Kit
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hCRP FRET 100

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rIgG FRET 100

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EUR 254.4

bcl-2(100/D5 + 124) Antibody

BNC041234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), CF405S conjugate, Concentration: 0.1mg/mL

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BNCAP1234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC811234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNUB1234-100 100uL
EUR 250.8
Description: Primary antibody against bcl-2(100/D5 + 124), Concentration: 0.2mg/mL

bcl-2(100/D5 + 124) Antibody

BNCH1234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC881234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNCB1234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), Biotin conjugate, Concentration: 0.1mg/mL

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BNC611234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC681234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), CF568 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC431234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), CF543 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC471234-100 100uL
EUR 238.8
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EUR 238.8
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bcl-2(100/D5 + 124) Antibody

BNC551234-100 100uL
EUR 238.8
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BNC801234-100 100uL
EUR 238.8
Description: Primary antibody against bcl-2(100/D5 + 124), CF680 conjugate, Concentration: 0.1mg/mL

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BNC051234-100 100uL
EUR 238.8
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Taq DNA Polymerase, Ultra Pure, 5 units/ul

T2016-100 100,000 units
EUR 3462

Turbidity Std Ratio 100 NTU

CRSR-100-100 100ML
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Inoculator 1 uL

DD42825 PK2000
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Inoculator 10 uL

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10 uL Syringe

MLCP-10muSYR-1 10 uL
EUR 65
Description: 10 uL Syringe

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EUR 73
Description: 250 uL Syringe

FUNNEL, 100 MM, PP

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EUR 56.4
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ATP Solution (100 mM)

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EUR 151.2

PBS Tablets (100 ml)

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EUR 196.8

Mouse IgG FRET 100

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EUR 254.4

Mouse IgM FRET 100

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100 BlotBot Reagent Reservoirs

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EUR 212.4
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AR02-P0003-100 100ug
EUR 319.2

Rv1009 (RpfB)-100

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Rv3875 (esxA)-100

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Rv3131 (NfnB)-100

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EUR 1359.6

Biotin TRF 100

BTTR-1006-100 1 Kit
EUR 286.8

Bcl-2 Antibody (Clone Bcl-2/100)

3195-100
EUR 430.8

amfiRivert Reverse Transcriptase, 200 units/ul , Superscript III Equivalent

A1202-100 100 rxns
EUR 355.2

amfiSure Taq DNA Polymerase, 1unit/ul, Including dNTP&MgCl2

P0310-100 4X250 Unit
EUR 505.2

Green Fluorescent Protein (GFP-fusion protein) ELISA Kit, 96 tests, Quantitative

800-420-GFP 1 kit
EUR 854.4

100 bp DNA Ladder (100 bp ~ 1,500 bp, with loading dye)

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Turbidity Std Non Ratio 100 NTU

CRS-100-100 100ML
EUR 191.52

Positive displacement micropipette Acura capillar 846 volume 60 - 75 - 80 - 90 - 100 uL

DD61948 EACH
EUR 373.92

ERLENMEYER FLASK, 100 ML, PP

4985P-100 6/pk
EUR 64.8
Description: Reusable Plastics; Reusable Erl Flasks

ERLENMEYER FLASK, 100 ML, PMP

4990P-100 6/pk
EUR 68.4
Description: Reusable Plastics; Reusable Erl Flasks

Triton® X-100 Detergent

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EUR 130.8

S-100?? Protein, Bovine Brain

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EUR 483.6

Reflex Clips, 7mm , 100/Pk

LC1001-100 100/pk
EUR 176.4

Bridge-It cAMP-PDE 100

PD1007-100 1 Kit
EUR 286.8

Rv2769c (PE27 protein)-100

AR02-P0001-100 100ug
EUR 574.8

2.5x12 cellogel 250µ (100)

EHCA1200-ST01-100 ea
EUR 104.4

2.5x17 cellogel 200µ (100)

EHCA1200-ST12-100 ea
EUR 147.6

4x17 cellogel 250µ (100)

EHCA1200-ST21-100 ea
EUR 202.8

4x17 cellogel 200µ (100)

EHCA1200-ST22-100 ea
EUR 202.8

5.7x14 cellogel 250µ (100)

EHCA1200-ST36-100 ea
EUR 192

5.7x14 cellogel 200µ (100)

EHCA1200-ST37-100 ea
EUR 192

5.7x17 cellogel 250µ (100)

EHCA1200-ST77-100 ea
EUR 267.6

Anti-Human Ferritin Antibody | MF-80A-100

MF-80A-100 1.0 mg
EUR 334
Description:

Anti-Human Ferritin Antibody | MF-80A-100 | Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

RNase H, 5u/ul

BEN0202 500U
EUR 199.2

Endonuclease IV, 2u/ul

BEN0591 100U
EUR 146.14

RNase I, 10u/ul

BEN0601 1KU
EUR 319.26

200 ul Pipet Tips

GR238007 Pack of 24
EUR 116.4

300 ul Pipet Tips

GR238018 Pack of 960
EUR 102

Sulfur 100 ug/g (100 PPM) for AA and ICP 100 grams in no.2 Diesel Fuel

SDFS-100-Y 100ML
EUR 102.6

Rabbit Anti-Bird IgM antibody, aff pure

90521-UL 100 ug
EUR 343.2

Sodium Pyruvate Solution, 100 mM Solution

CCM1753-100 100 mL
EUR 73.01

Microscope Slide Boxes,100-Place, Blue

LC7002-100 100/CS
EUR 967.2

Microscope Slide Boxes,100-Place, Green

LC7003-100 100/CS
EUR 967.2

Microscope Slide Boxes,100-Place, Red

LC7004-100 100/CS
EUR 967.2

Microscope Slide Boxes,100-Place, Yellow

LC7005-100 100/CS
EUR 967.2

Microscope Slide Boxes,100-Place, White

LC7006-100 100/CS
EUR 967.2

Human Exosome lysate positive protein control (10ug/ul), Size 50 ul

EXOAB-POS-1 500 ug
EUR 427.2

S-100 Antibody

3958-30T
EUR 175.2

Sodium Chloride tablets 100 ml

09-9103-100 100 ml
EUR 87.6

MTBK 20620 (PE protein)-100

AR02-P0005-100 100ug
EUR 1696.8

2.5x14 cellogel 190µ hr (100)

EHCA1200-ST08-100 ea
EUR 126

2.5x17 cellogel 190µ hr (100)

EHCA1200-ST13-100 ea
EUR 147.6

4x17 cellogel 190µ hr (100)

EHCA1200-ST23-100 ea
EUR 202.8

5.7x14 cellogel 190µ hr (100)

EHCA1200-ST38-100 ea
EUR 192

Turbidity Std Ratio 100 NTU

CRSR-100-1 1L
EUR 557.46

Turbidity Std Ratio 100 NTU

CRSR-100-500 500ML
EUR 399

QuantiChrom? LDH Cytotoxicity Assay Kit (C2LD-100)

C2LD-100 100
EUR 152.92
Description: Quantitative determination of cytotoxicity based on cellular lactate dehydrogenase release into cell culture medium by colorimetric (565nm) method. Procedure: 30 min. Kit size: 100 tests. Detection limit: 2 U/L. Shelf life: 6 months. Shipping: ambient tem

Meat sample spatulas (individually wrapped) 100/pk

MSSW-100 1 pk
EUR 73.2

DiagNano Fluorophore Labeled Gold Nanoparticles, 100 nm

GFL-100 1 mL
EUR 1263.6

Deacetylase Inhibitor Cocktail (100× in 70% DMSO)

K1017-100 100x1 ml
EUR 1395.6

Genorise® Plasmid DNA Extraction Kit 100

GR101073-100 100
EUR 172.8

Genorise® Universal DNA Mini Kit 100

GR101076-100 100
EUR 428.4

Genorise® Bone DNA Extraction Kit-100

GR101084-100 100
EUR 172.8

Genorise® Soil DNA Extraction Kit-100

GR101085-100 100
EUR 172.8

Genorise® Stool DNA Extraction Kit-100

GR101086-100 100
EUR 172.8

Universal DNA Marker (100 bp ~ 10,000 bp)

W2583-100 - Ask for price

Human DNA polymerase alpha - for 100 assays

HDPA1-100 100 assays
EUR 309.4
Description: This product includes 7 ul of 4 uM human DNA polymerase alpha catalytic subunit.

Human DNA polymerase beta - for 100 assays

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Single channel mini-pipette (130 mm) set of 5 pipettes(5, 10, 20, 50, 100 ul), autoclavable (note: 1 free pipette of 25 ul included)

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AMV Reverse Transcriptase, 10u/ul

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AMV Reverse Transcriptase, 10u/ul

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Taq DNA Polymerase, 5u/ul

B0089(D0089) 5X200U
EUR 112.2

Pfu DNA Polymerase, 5u/ul

B0093(D0090P) 500U
EUR 164.4


CONCLUSION
No other studies from other countries besides India and Nepal and there are insufficient data cost-effectiveness of each procedure. Better evidence is needed before any changes can be implemented. Future studies should have a long-term follow-up and conducted to minimize bias revealed in this review with a larger sample size to allow inspection of its side effects.

Benoit

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