Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract.

Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract.

BACKGROUND
Age -related cataract is a clouding of the lens, which occurs as a result of lens protein denaturation. Age -related cataract remains the leading cause of blindness globally, except in the most advanced countries. A key question is what is the best way of eliminating the lens, especially in low-income settings.


OBJECTIVE
To compare two different techniques of elimination of the lens in cataract surgery: the user is operating a small incision (MSICS) and extracapsular cataract extraction (ECCE).


METHOD
We searched CENTRAL (which contains the Cochrane Eyes and Trials Vision Group Register) (2014, Issue 8), Ovid MEDLINE, Ovid MEDLINE in process and Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946-September 2014), EMBASE ( January 1980 until September 2014), Latin America and the Caribbean Health Sciences Literature database (LILACS) (January 1982 to September 2014), web of Science Conference Proceedings Citation Index, Science (CPCI-S), (January 1990 to September 2014), which metaRegister of Controlled Trials (mRCT) ), and the World Health Organization (WHO) International Clinical Trials Registry platform (ICTRP) . We do not use date or language restrictions in the electronic searches for trials. Last we are looking for an electronic database on 23 September 2014.


METHOD
We included randomized controlled trials (RCTs) only. Participants in the trials were people with age-related cataract. We included trials in which MSICS with posterior chamber intraocular lens (IOL) implant compared to ECCE with posterior chamber IOL implant.


METHOD
Data were collected independently by two authors. We aim to collect data on presenting visual acuity of 6/12 or better and best corrected visual acuity less than 6/60 in three months and one year after surgery. Other results included intraoperative complications, complications of long-term (one year or more after surgery), quality of life, and cost effectiveness. There is not enough data available from the trial and to conduct a meta-analysis.

 Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract.
Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract.


RESULTS
Three randomized trial allocate people with age-related cataract to MSICS or ECCE included in this review (n = 953 participants). Two trials conducted in India and one in Nepal. experimental methods, such as random allocation and allocation concealment, not clearly explained; only in one experiment was an attempt to conceal the outcome assessors. Three studies reported follow-up six to eight weeks after surgery. In two studies, a participant in the group MSICS achieved without the aid of visual acuity 6/12 or 6/18 or better than the ECCE group, but overall no more than 50% of people achieve a good functional vision in two studies.

10/806 (1.2%) of those enrolled in the two trials had poor outcomes after surgery (best corrected vision of less than 6/60) with no evidence of a difference in risk between the two techniques (risk ratio (RR) 1.58 , 95% confidence interval (CI) 0.45 to 5.55). Surgically induced astigmatism more common with ECCE procedure of MSICS in two trials that reported this outcome. In one study there more complications intra and post-surgery in MSICS group. One study reported that the cost of two similar procedures.

dsGreen for Real-Time PCR, 100×, 100 uL

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GFP Antibody, 10 uL

P601-10 NULL
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Cyanine5 azide, 100 uL, 10 mM/DMSO

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CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF680 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF405S conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF405M conjugate, Concentration: 0.1mg/mL

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Description: Primary antibody against CD1b(100-1A5), CF640R conjugate, Concentration: 0.1mg/mL

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Description: Primary antibody against CD1b(100-1A5), CF568 conjugate, Concentration: 0.1mg/mL

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Description: Primary antibody against CD1b(100-1A5), CF488A conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF594 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF770 conjugate, Concentration: 0.1mg/mL

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Description: Primary antibody against CD1b(100-1A5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

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CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), Biotin conjugate, Concentration: 0.1mg/mL

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Description: Primary antibody against CD1b(100-1A5), CF680R conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), Concentration: 0.2mg/mL

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Description: Primary antibody against CD1b(100-1A5), CF543 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

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Description: Primary antibody against CD1b(100-1A5), CF647 conjugate, Concentration: 0.1mg/mL

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Description: Primary antibody against CD1b(100-1A5), CF555 conjugate, Concentration: 0.1mg/mL

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Description: Primary antibody against CD1b(100-1A5), CF660R conjugate, Concentration: 0.1mg/mL

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Human IgG/RF-adsorbent (Adsorb 50 serum samples of 100 ul)

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bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF680 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF405M conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF405S conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF640R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), CF543 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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Description: Primary antibody against bcl-2(100/D5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC810045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCB0045-100 100uL
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Description: Primary antibody against bcl-2(100/D5), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNUB0045-100 100uL
EUR 209.00
Description: Primary antibody against bcl-2(100/D5), Concentration: 0.2mg/mL

bcl-2(100/D5) Antibody

BNC470045-100 100uL
EUR 199.00
Description: Primary antibody against bcl-2(100/D5), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

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EUR 199.00
Description: Primary antibody against bcl-2(100/D5), CF555 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC610045-100 100uL
EUR 199.00
Description: Primary antibody against bcl-2(100/D5), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC700045-100 100uL
EUR 199.00
Description: Primary antibody against bcl-2(100/D5), CF770 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC940045-100 100uL
EUR 199.00
Description: Primary antibody against bcl-2(100/D5), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC680045-100 100uL
EUR 199.00
Description: Primary antibody against bcl-2(100/D5), CF568 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC880045-100 100uL
EUR 199.00
Description: Primary antibody against bcl-2(100/D5), CF488A conjugate, Concentration: 0.1mg/mL

MTBK_20640-100

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EUR 1133.00

Etoposide (100 mM)

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hAlbumin FRET 100

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hAlbumin TRF 100

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hCRP FRET 100

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hCRP TRF 100

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hInsulin FRET 100

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hInsulin TRF 100

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hIgG TRF 100

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rIgG FRET 100

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bcl-2(100/D5 + 124) Antibody

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Description: Primary antibody against bcl-2(100/D5 + 124), CF770 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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Description: Primary antibody against bcl-2(100/D5 + 124), CF680 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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Description: Primary antibody against bcl-2(100/D5 + 124), Concentration: 0.2mg/mL

bcl-2(100/D5 + 124) Antibody

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Description: Primary antibody against bcl-2(100/D5 + 124), CF405S conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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Description: Primary antibody against bcl-2(100/D5 + 124), CF405M conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC401234-100 100uL
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Description: Primary antibody against bcl-2(100/D5 + 124), CF640R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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EUR 199.00
Description: Primary antibody against bcl-2(100/D5 + 124), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC681234-100 100uL
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Description: Primary antibody against bcl-2(100/D5 + 124), CF568 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNCH1234-100 100uL
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Description: Primary antibody against bcl-2(100/D5 + 124), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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Description: Primary antibody against bcl-2(100/D5 + 124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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Description: Primary antibody against bcl-2(100/D5 + 124), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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Description: Primary antibody against bcl-2(100/D5 + 124), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC431234-100 100uL
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Description: Primary antibody against bcl-2(100/D5 + 124), CF543 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC471234-100 100uL
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Description: Primary antibody against bcl-2(100/D5 + 124), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC551234-100 100uL
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Description: Primary antibody against bcl-2(100/D5 + 124), CF555 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC941234-100 100uL
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Description: Primary antibody against bcl-2(100/D5 + 124), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

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Taq DNA Polymerase, Ultra Pure, 5 units/ul

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PBS Tablets (100 ml)

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ATP Solution (100 mM)

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100 BlotBot Reagent Reservoirs

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Bcl-2 Antibody (Clone Bcl-2/100)

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100 bp DNA Ladder (100 bp ~ 1,500 bp, with loading dye)

W0636-100 NULL
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Green Fluorescent Protein (GFP-fusion protein) ELISA Kit, 96 tests, Quantitative

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Human Exosome lysate positive protein control (10ug/ul), Size 50 ul

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2.5x14 cellogel 190µ hr (100)

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5.7x14 cellogel 190µ hr (100)

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AMV Reverse Transcriptase, 10u/ul

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Tsg DNA Polymerase, 5u/ul

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Tsg PlusDNA Polymerase, 5u/ul

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PHI29 DNA Polymerase, 10u/ul

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C2LD-100 100
EUR 127.43
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitative determination of cytotoxicity based on cellular lactate dehydrogenase release into cell culture medium by colorimetric (565nm) method. Procedure: 30 min. Kit size: 100 tests. Detection limit: 2 U/L. Shelf life: 6 months. Shipping: ambient tem

Deacetylase Inhibitor Cocktail (100× in 70% DMSO)

K1017-100 100x1 ml
EUR 1163.00

DiagNano Fluorophore Labeled Gold Nanoparticles, 100 nm

GFL-100 1 mL
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Meat sample spatulas (individually wrapped) 100/pk

MSSW-100 1 pk
EUR 61.00

Universal DNA Marker (100 bp ~ 10,000 bp)

W2583-100 NULL
EUR NULL

Albumin-X, Albumin (multiple species) removal kit (sufficient to remove 2-3 mg albumin or process ~50-100 ul serum; 10 mini-columns ~250 ul resin)

700-300-10 1 kit
EUR 286.00

100 mM Triton X-100

603 100 ml
EUR 98.00

Rabbit Anti-Bird IgM antibody, aff pure

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EUR 286.00

Rv0350 (Heat Shock Protein 70)-100

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EUR 277.00

Rv2299c (Heat Shock Protein 90)-100

AR02-P0004-100 100ug
EUR 351.00

2.5x13 cellogel 200µ practiga punched (100)

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5.7x14 cellogel 200µ pratiga punched (100)

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5.7x14.5 cellogel 200µ beckman punched (100)

EHCA1200-ST53-100 ea
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GFP Antibody

3999-100
EUR 354.00

SP-100 Polyclonal Antibody

ABP56261-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human SP-100 at AA range: 250-330
  • Applications tips:
Description: A polyclonal antibody for detection of SP-100 from Human. This SP-100 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human SP-100 at AA range: 250-330

SP-100 Polyclonal Antibody

ABP56261-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human SP-100 at AA range: 250-330
  • Applications tips:
Description: A polyclonal antibody for detection of SP-100 from Human. This SP-100 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human SP-100 at AA range: 250-330

SP-100 Polyclonal Antibody

ABP56261-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from the Internal region of human SP-100 at AA range: 250-330
  • Applications tips:
Description: A polyclonal antibody for detection of SP-100 from Human. This SP-100 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human SP-100 at AA range: 250-330

CREB (Ab-100) Antibody

33210-100ul 100ul
EUR 252.00

CREB (Ab-100) Antibody

33210-50ul 50ul
EUR 187.00

Tag-100 tag Antibody

abx019172-100ug 100 ug
EUR 356.00
  • Shipped within 5-10 working days.

Apo B48 / 100 Antibody

abx023238-1ml 1 ml
EUR 509.00
  • Shipped within 5-10 working days.

Polyclonal S-100 Antibody

APR13176G 0.1mg
EUR 484.00
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human S-100 . This antibody is tested and proven to work in the following applications:

CD1b(100-1A5) Antibody

BNCA1044-250 250uL
EUR 383.00
Description: Primary antibody against CD1b(100-1A5), APC conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC801044-500 500uL
EUR 544.00
Description: Primary antibody against CD1b(100-1A5), CF680 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNUM1044-50 50uL
EUR 395.00
Description: Primary antibody against CD1b(100-1A5), 1mg/mL

CD1b(100-1A5) Antibody

BNC041044-500 500uL
EUR 544.00
Description: Primary antibody against CD1b(100-1A5), CF405S conjugate, Concentration: 0.1mg/mL


CONCLUSION
No other studies from other countries besides India and Nepal and there are insufficient data cost-effectiveness of each procedure. Better evidence is needed before any changes can be implemented. Future studies should have a long-term follow-up and conducted to minimize bias revealed in this review with a larger sample size to allow inspection of its side effects.

Benoit

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